Spatially resolved transcriptomic profiling identifies distinct signatures in parenchymal and vascular microenvironments in Alzheimer's Disease with Cerebral Amyloid Angiopathy - PubMed
3 hours ago
- #Cerebral Amyloid Angiopathy
- #Alzheimer's Disease
- #Spatial Transcriptomics
- Spatially resolved transcriptomic profiling identifies distinct gene expression signatures in parenchymal and vascular microenvironments in Alzheimer's Disease (AD) with Cerebral Amyloid Angiopathy (CAA).
- The study highlights differences in how shared pathways, such as the matrisome, are upregulated in vascular versus parenchymal amyloid deposition.
- Findings suggest the need for compartment-specific therapeutic strategies to target amyloid pathology effectively and minimize treatment-related complications.
- The research utilized postmortem brain tissue from individuals with mixed AD/CAA pathology for spatial whole-transcriptomic profiling.
- Results emphasize the dynamic and context-dependent nature of microenvironments in AD/CAA, pointing to distinct responses to amyloid deposition in different brain compartments.