Initiation of Tertiary Lymphoid Structures for Cancer Immunotherapy - PubMed
3 hours ago
- #Tumor Microenvironment
- #Cancer Immunotherapy
- #Tertiary Lymphoid Structures
- Tertiary lymphoid structures (TLSs) are ectopic lymphoid aggregates formed in chronic inflammatory or tumor microenvironments (TMEs).
- TLS initiation is crucial for mounting an effective antitumor immune response.
- The initiation phase depends on the interplay between lymphoid tissue inducer and organizer cells, regulated by cytokines and chemokines.
- TLSs reshape the TME, enhance antigen presentation, and recruit immune cells to boost antitumor responses.
- Potential strategies to modulate TLS initiation are discussed, highlighting their role as targets in cancer immunotherapy.