NAD+ hydrolysis catalyzed by SelO is required for mitochondrial homeostasis - PubMed
3 days ago
- #mitochondrial homeostasis
- #NAD+
- #selenocysteine
- NAD+ hydrolysis by SelO is essential for mitochondrial homeostasis.
- SelO converts NAD+ to NMN and AMP using Mn2+ as a cofactor.
- The reaction depends on SelO's C-terminal CSS residues, especially selenocysteine 667.
- SelO's activity is linked to lipid utilization through direct association with FAO enzymes.
- The reaction responds to elevated mitochondrial matrix pH, protecting against metabolic overactivation.
- This mechanism is conserved in both mammalian cells and bacteria.
- Findings highlight the physiological importance of NAD+ regulation in prokaryotes and eukaryotes.