Achieving LDL-C <1.0 mmol/L and cardiovascular outcomes in patients with coronary artery disease who received percutaneous coronary intervention - PubMed
4 hours ago
- #cardiovascular outcomes
- #LDL-C goals
- #coronary artery disease
- Achieving LDL-C levels below 1.0 mmol/L significantly reduces cardiovascular risks in coronary artery disease patients post-percutaneous coronary intervention (PCI).
- In a multi-center study of 2560 patients, those with on-treatment LDL-C <1.0 mmol/L (9.8% of participants) had lower primary and secondary outcome risks compared to higher LDL-C groups.
- Patients with extreme risk, such as polyvascular disease or recurrent ASCVD history, showed LDL-C <1.0 mmol/L in about 10% of cases, benefiting from intensified lipid-lowering therapies.
- The study supports more aggressive lipid-lowering strategies, including high-intensity statins, ezetimibe, and PCSK9 inhibitors, to achieve LDL-C <1.0 mmol/L for improved cardiovascular outcomes.
- Benefits of lower LDL-C were consistent across age, gender, CAD types, and traditional risk factors, reinforcing guideline recommendations for LDL-C targets in high-risk patients.