HC-HA/PTX3 from amniotic membrane reprograms human corneal fibroblasts to neural crest progenitors by switching from canonical to noncanonical TGFβ signaling - PubMed
4 hours ago
- #amniotic membrane
- #neural crest progenitors
- #TGFβ signaling
- HC-HA/PTX3 from amniotic membrane reprograms human corneal fibroblasts (HCF) to neural crest progenitors.
- Reprogramming involves switching from canonical to noncanonical TGFβ signaling.
- HC-HA/PTX3 suppresses TGFβ1 SMAD-mediated canonical signaling by sequestering TβRII in lipid rafts.
- Nuclear translocation of cyclin D1 and CD44 intracellular domain (CD44ICD) facilitates reprogramming.
- HC-HA/PTX3 can be used to reverse scarring and promote corneal regeneration.
- Ethical approvals were obtained for the use of human placental and corneal tissues in the study.