Brain lipidomics identifies mitochondrial redox dysfunction and metabolic trade-offs associated with Parkinson's disease-like pathology induced by Nanoplastics exposure - PubMed
7 hours ago
- #mitochondrial dysfunction
- #nanoplastics
- #Parkinson's disease
- Nanoplastics exposure is linked to neurotoxicity and Parkinson's disease-like pathology.
- High-resolution lipidomics in Drosophila melanogaster showed nanoplastics-induced mitochondrial lipid remodeling.
- Exposure led to increased lipid peroxidation, mitochondrial dysfunction, and redox imbalance.
- Dopaminergic neurochemistry was impaired, with decreased tyrosine hydroxylase and dopamine levels.
- Antioxidant N-acetylcysteine (NAC) treatment restored mitochondrial function and neurotransmitter levels.
- Findings highlight mitochondrial redox-lipid interactions as key in nanoplastics-induced neurodegeneration.