Self-reinforcing IL-1b signaling accelerates the development and recurrence of TCF3::HLF-positive B-ALL - PubMed
3 hours ago
- #B-ALL
- #leukemia
- #IL-1β signaling
- TCF3::HLF fusion protein defines a highly aggressive and incurable subtype of B-ALL.
- Self-reinforcing IL-1β signaling networks drive disease progression in TCF3::HLF B-ALL.
- TCF3::HLF B-ALL cells show upregulation of inflammatory cytokines like IL1B, IL6, and IFNG.
- Genetic deletion of IL1B or IL1R1 suppresses leukemic growth and reduces bone destruction.
- TCF3::HLF binds to an intronic regulatory element within the IL1B locus.
- IL1B induction is stronger at relapse compared to diagnosis in patient samples.
- IL-1β blockade is highlighted as a potential therapeutic strategy for TCF3::HLF B-ALL.