Association between healthy plant-based diet-lifestyle (hPDI-Lifestyle) score and incidence of coronary heart disease, and effect modification by genetic predisposition: a prospective analysis in a po
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- #Plant-based diet
- #Genetic predisposition
- #Cardiovascular health
- Study evaluates the association between a healthy plant-based diet-lifestyle (hPDI-Lifestyle) score and coronary heart disease (CHD) incidence.
- Analyzed 7764 participants from the Rotterdam Study, with a mean age of 63 and 60.1% women.
- Ideal adherence to hPDI-Lifestyle was linked to a 20% lower CHD risk in low genetic risk participants and 44% lower in high genetic risk participants.
- Supports adopting a healthful plant-based diet combined with lifestyle changes (non-smoking, physical activity, moderate sleep) for personalized CHD prevention.
- Suggests further investigation into how genetic predisposition modifies the effect of lifestyle on CHD prevention.