Multiple sclerosis synaptic connectome: Insights from fluid biomarkers - PubMed
4 hours ago
- #neurodegeneration
- #multiple sclerosis
- #synaptic biomarkers
- Multiple sclerosis is a chronic immune-mediated and degenerative disease of the central nervous system.
- Brain network disconnection plays a significant role in clinical progression and irreversible disability in multiple sclerosis.
- Pathologic changes include demyelination, axonal transection, and atrophy of gray matter structures.
- Synaptic dysfunction is increasingly recognized as a key factor in brain connectome changes in multiple sclerosis.
- Fluid biomarkers, such as synaptic proteins in cerebrospinal fluid and blood, may help measure synaptic integrity.
- Presynaptic markers (SNAP-25, VAMP-2, β-synuclein), postsynaptic proteins (neurogranin, NPTX2), and astrocyte-derived proteins are under investigation.
- Ongoing research aims to define the temporal dynamics of these markers and their relationship with neuroinflammatory and neurodegenerative processes.