Effect of a polygenic risk score in patients with late-onset, early-onset, familial, or hereditary colorectal cancer - PubMed
3 hours ago
- #risk stratification
- #colorectal cancer
- #polygenic risk score
- A high polygenic risk score (PRS) significantly increases colorectal cancer (CRC) risk across clinical risk groups compared to population controls.
- High PRS doubles CRC risk in early-onset sporadic and familial CRC, with cumulative incidences of 24% before age 50 and 13% before age 75.
- PRS is higher in early-onset sporadic CRC than late-onset sporadic CRC.
- In Lynch syndrome, PRS in non-carriers falls between Lynch syndrome CRC patients and population controls.
- Non-Lynch syndrome individuals with MSI/dMMR tumors have lower PRS than those with pMMR/MSS tumors, showing no difference from Lynch syndrome CRC cases.
- PRS most strongly affects CRC risk in unexplained early-onset and familial CRC, while its effect in Lynch syndrome depends on gene penetrance and study design.