Retinoic Acid Alleviates TGEV-Induced Ferroptosis by Activating the p62-NRF2-GPX4/HO-1 Pathway and Iron Metabolism in Intestinal Epithelial Cells - PubMed
4 hours ago
- #retinoic acid
- #ferroptosis
- #TGEV
- Transmissible gastroenteritis virus (TGEV) disrupts iron homeostasis in intestinal epithelial cells, leading to free iron accumulation, reactive oxygen species (ROS) generation, and ferroptosis.
- TGEV infection inhibits the p62-NRF2-GPX4/HO-1 antioxidant signaling pathway, worsening ferroptosis.
- Retinoic acid (RA) alleviates TGEV-induced ferroptosis by regulating iron metabolism and activating the p62-NRF2-GPX4/HO-1 pathway.
- The study identifies ferroptosis as a key mechanism in TGEV-induced intestinal injury, suggesting potential therapeutic strategies.