Hypoxic regulation of chromatin and gene transcription - PubMed
3 hours ago
- #Chromatin Regulation
- #Histone Methylation
- #Hypoxia
- Hypoxia adaptation in eukaryotes involves HIF transcription factor regulated by 2-oxoglutarate-dependent oxygenases, which also include histone demethylases.
- Histone methylation increases globally in hypoxia across gene loci regardless of transcriptional changes, as shown using drosophila chromatin spike-in normalisation.
- Increased H3K4me3 and H3K36me3 at direct HIF targets are HIF-dependent and linked to transcriptional engagement, but global trimethylation changes do not predict transcriptional direction.