FAP+ fibroblasts promote C1QC+ macrophages infiltration via WNT2 signaling to exacerbate T cell exhaustion in oral squamous cell carcinoma - PubMed
3 hours ago
- #Oral squamous cell carcinoma
- #Immunosuppression
- #Tumor microenvironment
- FAP+ fibroblasts promote C1QC+ macrophages infiltration via WNT2 signaling in oral squamous cell carcinoma (OSCC).
- FAP+ fibroblasts secrete WNT2, activating β-catenin signaling in macrophages, which upregulates C1QC and M2 markers.
- C1QC+ macrophages exhibit tumor-promoting functions, including enhanced fatty acid metabolism and immunosuppressive signaling.
- C1QC+ macrophages recruit Tregs via CCL2 secretion and induce T cell exhaustion.
- FAP expression correlates with poor prognosis and predicts resistance to anti-PD-1 therapy in OSCC.
- Inhibition of FAP enhances the efficacy of anti-PD-1 treatment by reshaping the immune landscape.