Highly Biomimetic Ectodermal Epithelial Organoids for Epithelial Barrier Stimulation Assays - PubMed
3 hours ago
- #ectodermal epithelial organoids
- #epithelial barrier
- #toxicity screening
- A novel method for creating ectodermal epithelial organoids (EEOs) mimics native tissue complexity by downregulating TGF-β signaling.
- EEOs accurately replicate key barrier components like the stratum corneum and intercellular junctions.
- These organoids improve pre-clinical toxicity screening for pharmaceuticals and biomaterials on oral mucosa and skin.
- Validation shows EEOs detect dose-dependent drug cytotoxicity and previously unseen nanomaterial-induced damage.
- The model offers a robust platform for epithelial barrier stimulation tests, enhancing safety predictions in drug development.