Targeting Gβγ subunits in hypothalamic AgRP neurons to treat obesity - PubMed
9 hours ago
- #AgRP neurons
- #Gβγ subunits
- #Obesity
- Targeting Gβγ subunits in hypothalamic AgRP neurons presents a novel approach to treat obesity.
- Gallein, a Gβγ inhibitor, reduces diet-induced obesity by suppressing appetite through inhibition of AgRP neuronal activity.
- Overexpression of Gβγ in AgRP neurons leads to hyperphagia and obesity, highlighting its critical role in energy balance.
- Gβγ subunits increase AMPK activity, promoting mitochondrial fatty acid oxidation and ATP production, thereby enhancing AgRP neuron activity.
- Gallein emerges as a promising therapeutic candidate for obesity and related metabolic disorders by specifically targeting Gβγ subunits.