Perturbations of Diet and Gut Signatures Persist During Remission in Crohn's Disease Despite Effective Immune Suppression - PubMed
3 days ago
- #Crohn's Disease
- #Gut Microbiome
- #Diet
- Perturbations in diet and gut signatures persist during Crohn's Disease (CD) remission despite effective immune suppression.
- Study analyzed diet, ileal transcriptomics, microbiomics, and metabolomics in CD patients (remission and active) vs. non-IBD controls.
- Key findings: Decreased adaptive T cell and innate granulocyte pathways in remission, but increased epithelial antimicrobial pathways (e.g., DUOX2).
- Remission patients showed persistent pathogenic gut microbial composition, metabolic alterations, and less healthy dietary habits (e.g., higher ultraprocessed food intake, lower fiber/vegetable consumption).
- Ultraprocessed food intake negatively correlated with mucin glycosylation genes, crucial for gut barrier homeostasis.
- Interventions targeting diet, epithelial health, and microbial/metabolic functions may promote deeper, longer-lasting remission.