HIF-1α mediated placental ischemic signaling in the development of early-onset preeclampsia - PubMed
7 hours ago
- #Preeclampsia
- #Placental Ischemia
- #HIF-1α
- Early-onset preeclampsia is a severe placental disorder caused by impaired uteroplacental perfusion and placental ischemia.
- HIF-1α-mediated hypoxic signaling is a central regulator linking placental ischemia to molecular and clinical manifestations.
- Controlled hypoxia in early gestation aids normal trophoblast differentiation and vascular remodeling.
- Excessive hypoxia stabilizes HIF-1α, leading to defective trophoblast invasion and impaired spiral artery remodeling.
- Sustained HIF-1α activation causes mitochondrial dysfunction, oxidative stress, and amplifies placental injury.
- HIF-1α promotes antiangiogenic programs, including sFlt-1 upregulation, leading to systemic angiogenic imbalance and maternal endothelial dysfunction.
- Understanding HIF-1α-centered signaling can improve biomarker development and targeted therapies for early-onset preeclampsia.