Cannabinoid type 2 receptor regulates skeletal muscle regeneration by NLRP3-GSDMD mediated macrophage pyroptosis after injury - PubMed
7 hours ago
- #CB2 receptor
- #muscle regeneration
- #macrophage pyroptosis
- CB2R activation protects skeletal muscle after injury by inhibiting PI3K/AKT/NF-κB pathway.
- CB2R deficiency leads to increased macrophage pyroptosis via NLRP3 inflammasome, worsening inflammation and impairing muscle repair.
- CB2R regulates non-cell-autonomous mechanisms by controlling macrophage-driven inflammatory signals to support muscle regeneration.