A Risk Factor Atlas for Allergy-Related Airway Diseases: Evidence From Multi-Biobank Genetic Study - PubMed
4 hours ago
- #allergy diseases
- #genetic study
- #risk factors
- The study conducted a meta-analysis of Mendelian randomization estimates from multi-biobank sources to examine 83 factors affecting allergy-related airway diseases (AADs).
- Data sources included FinnGen, UK Biobank, and large consortia, covering asthma, allergic rhinitis, chronic rhinosinusitis, and nasal polyps with significant case-control numbers.
- Risk factors identified for asthma include social isolation, smoking, sedentary behavior, obesity, insomnia, mental health disorders, and autoimmune conditions.
- Protective factors for asthma include education, higher income, cheese intake, sleep duration, and well-being.
- Risk factors for allergic rhinitis include social isolation, CRP, Crohn's disease, GERD, insomnia, MDD, neuroticism, and atopic dermatitis, while well-being lowers risk.
- For chronic rhinosinusitis, sedentary time, mental health disorders, autoimmune diseases, and hypothyroidism increase risk, whereas coffee intake and well-being decrease risk.
- Smoking duration, rheumatoid arthritis, atopic dermatitis, and type 1 diabetes increase nasal polyp risk, while fresh fruit intake reduces it.
- The findings provide potential causal evidence and actionable targets for the primary prevention of AADs.