SREBP1 knockdown triggers ferroptosis by suppressing the Nrf2-XCT/GPX4 axis in ovarian cancer - PubMed
4 days ago
- #ovarian cancer
- #lipid metabolism
- #ferroptosis
- SREBP1 knockdown induces ferroptosis in ovarian cancer by suppressing the Nrf2-XCT/GPX4 axis.
- Silencing SREBP1 leads to decreased GSH levels, reduced XCT and GPX4 expression, and increased lipid peroxidation.
- SREBP1 silencing suppresses ovarian cancer cell proliferation and induces cell cycle arrest.
- It also inhibits epithelial-mesenchymal transition (EMT) and lipid synthesis in ovarian cancer cells.
- SREBP1 promotes Nrf2 degradation via ubiquitination, reducing XCT and GPX4 expression, which triggers ferroptosis.
- The study identifies SREBP1 as a potential therapeutic target and prognostic biomarker in ovarian cancer.