Rotator Cuff Impingement Damages the Organelles of Tenocytes, Resulting in Excessive Tenocyte Apoptosis and Tendinopathy - PubMed
4 hours ago
- #apoptosis
- #rotator cuff injury
- #tendinopathy
- Rotator cuff impingement syndrome leads to supraspinatus tendinopathy, causing pain and functional impairment.
- Excessive apoptosis of tenocytes is a key pathological mechanism in supraspinatus tendinopathy and rotator cuff tears.
- Mitochondrial degeneration and ER stress-induced apoptosis are significant in chronic multisystem diseases and may contribute to tendinopathy.
- A mouse model with acromion impingement was used to study mitochondrial dysfunction and ER stress in tendon cells.
- Results showed reduced tendon failure force and stiffness, cellular rounding, and collagen disorganization in the impingement group.
- Apoptotic indices peaked at 4 weeks, with upregulation of mitochondrial apoptotic pathway markers and ER stress mediators.
- TEM revealed mitochondrial depletion, loss of cristae, and ER system expansion in the experimental group.
- The study concludes that impingement injuries trigger mitochondria and ER-linked apoptotic pathways, leading to tendinopathy.
- Findings contribute to understanding early organelle-level pathological characteristics of tendinopathy.