DPP4 suppresses pancreatic cancer growth by enhancing ferroptosis sensitivity through stabilization of ACSL4 - PubMed
3 hours ago
- #DPP4
- #Pancreatic Cancer
- #Ferroptosis
- DPP4 expression is significantly downregulated in pancreatic ductal adenocarcinoma (PDAC) tumor tissues compared to adjacent non-tumorous tissues.
- DPP4 overexpression in PDAC cell lines inhibits cell proliferation, induces G1-S cell cycle arrest, and sensitizes cells to erastin-induced ferroptosis.
- DPP4 stabilizes ACSL4 by inhibiting its ubiquitin-mediated degradation, promoting ACSL4-dependent lipid peroxidation.
- ACSL4 knockdown rescues DPP4 overexpression-induced ferroptosis and lipid ROS accumulation.
- The DPP4-ACSL4 axis is identified as a potential therapeutic target to enhance ferroptosis-based strategies against PDAC.