Peripheral blood inflammatory ratios predict efficacy and toxicity of CAR-T cell immunotherapy in relapsed/refractory multiple myeloma - PubMed
3 hours ago
- #multiple myeloma
- #CAR-T therapy
- #inflammatory biomarkers
- Peripheral blood inflammatory ratios (NLR, MLR, PLR) predict efficacy and toxicity of CAR-T cell therapy in relapsed/refractory multiple myeloma (R/R MM).
- Optimal cut-offs for NLR, MLR, and PLR were 2.55, 0.35, and 145, respectively.
- Low baseline inflammatory ratios correlated with better CAR transgene expansion, treatment response, and longer progression-free survival (PFS).
- High inflammatory ratios were associated with severe cytokine release syndrome (CRS) and elevated IL-6 and ferritin levels.
- The Cellular Inflammatory Prognostic Index (CIPI) effectively stratified patients into low-, intermediate-, and high-risk groups with distinct PFS outcomes.
- CIPI score and high tumor burden were independent prognostic factors for PFS in multivariate analysis.