Defective Trophoblast Differentiation, Endothelial Dysfunction, and Immune Dysregulation in Preeclampsia Coalesce on a Placental VGLL3-Centered Gene Network - PubMed
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- #placental gene network
- #VGLL3
- #preeclampsia
- VGLL3, a transcription coregulator in the Hippo pathway, is upregulated in preeclamptic placentas.
- VGLL3 promotes immune activation, impairs trophoblast differentiation, and induces endothelial dysfunction, contributing to hypertension, fetal growth restriction, and offspring mortality.
- VGLL3 acts upstream of key preeclampsia processes, including the production of sFLT1, a major disease biomarker.
- Targeting VGLL3 via genetic deletion in mice or therapeutic inhibition in human placentas protects against preeclampsia and alleviates disease pathology.
- VGLL3 is identified as a promising novel therapeutic target for preeclampsia, a condition affecting about 1 in 10 pregnancies.