Association of metformin with lung function decline and mortality in fibrotic interstitial lung disease: an observational cohort study - PubMed
3 hours ago
- #Metformin
- #Interstitial Lung Disease
- #Lung Function
- Study investigates metformin's effect on lung function decline and mortality in fibrotic interstitial lung disease (ILD).
- Analysis of 2,226 patients from the Canadian Registry for Pulmonary Fibrosis (CARE-PF) showed no significant association between metformin use and attenuation of forced vital capacity decline.
- No significant benefit was found in subgroups with idiopathic pulmonary fibrosis or diabetes.
- Trend toward increased mortality or transplant risk with metformin use, though not statistically significant after adjustments.
- Despite laboratory evidence of antifibrotic properties, metformin did not significantly alter lung function decline in fibrotic ILD.