ALS and Huntington Disease: Unraveling the Connections between TDP-43 and Huntingtin - PubMed
12 hours ago
- #TDP-43
- #neurodegenerative diseases
- #Huntingtin
- ALS and Huntington Disease (HD) are lethal neurodegenerative diseases affecting motor function.
- TDP-43 is associated with 97% of ALS cases, while HD is caused by polyglutamine expansion in the HTT protein.
- Recent evidence suggests commonalities between TDP-43 and HTT in both ALS and HD.
- ALS involves progressive loss of motor neurons and degeneration of the brainstem and spinal cord.
- HD is characterized by progressive neuron loss in the brain, particularly the striatum, leading to motor, cognitive, and behavioral changes.
- Links between HTT and TDP-43 extend to related neurodegenerative diseases like frontotemporal dementia (FTD) and spinocerebellar ataxia type 2 (SCA2).
- Understanding commonalities between TDP-43 and HTT may help identify broad-spectrum disease risk factors and overlapping treatment targets.