Advanced MRI of the choroid plexus: Applications in aging and dementia - PubMed
a day ago
- #Choroid Plexus
- #MRI
- #Dementia
- The choroid plexus (ChP) is a vascularized epithelial organ in the brain ventricles, responsible for CSF production, blood-CSF barrier regulation, and neuroimmune responses.
- ChP plays a role in brain clearance pathways, aiding CSF-interstitial fluid exchange and waste removal.
- Disruption of ChP/BCSFB is linked to aging and neurodegenerative disorders like Alzheimer's disease.
- Advanced MRI techniques enable non-invasive assessment of ChP microstructure, perfusion, permeability, and water exchange.
- MRI-derived ChP integrity indices correlate with cognitive status and may help in early detection and monitoring of dementia.
- Continued development of MRI approaches is crucial for understanding ChP's role in neurodegeneration and its clinical applications.