PIEZO1 regulates smooth muscle cell plasticity by integrating mechanical stretch with glycolytic metabolism - PubMed
4 hours ago
- #PIEZO1
- #vascular remodeling
- #glycolytic metabolism
- PIEZO1 plays a critical role in pulmonary artery smooth muscle cell (PASMC) plasticity by integrating mechanical stretch with glycolytic metabolism.
- Under hypoxia, PIEZO1 activation promotes glycolysis in PASMCs via HIF1α and PFKFB3, leading to lactate production and cell proliferation.
- In severe pulmonary injury, hyper-activated PIEZO1 activates PPARγ, which antagonizes TGFβ signaling, restraining glycolysis and proliferation via FBP1.
- Loss of smooth muscle Piezo1 attenuates hypoxia-induced PASMC growth and vascular remodeling but aggravates pulmonary fibrosis in mice.
- The study identifies PIEZO1 as a key mediator of mechano-metabolic coupling in PASMCs during pulmonary vascular remodeling.