NPLOC4 Inhibition Remodels Tumor Microenvironment via M2-to-M1 Macrophage Reprogramming and Boosts Anti-PD-1 Response in Liver Cancer - PubMed
3 days ago
- #immunotherapy
- #hepatocellular carcinoma
- #NPLOC4
- NPLOC4 inhibition remodels the tumor microenvironment by reprogramming M2 macrophages to M1, enhancing anti-PD-1 response in liver cancer.
- NPLOC4+ TAMs inhibit antitumor immune responses by promoting RIG-I degradation, negatively impacting HCC patient prognosis.
- NPLOC4 suppresses the type I interferon pathway in TAMs, promotes M2 polarization, and reduces CD8+ T-cell infiltration, creating an immunosuppressive HCC microenvironment.
- Disulfiram/copper (DSF/Cu) targets NPLOC4, and combining DSF/Cu with PD-1 therapy significantly inhibits HCC growth.
- Targeting NPLOC4+ TAMs enhances resistance to anti-PD-1 therapy, presenting a novel immune target for HCC treatment.