The Wnt receptor Frizzled3 (FZD3) drives aggressive phenotypes in small cell lung cancer - PubMed
3 hours ago
- #Wnt signaling
- #SCLC
- #FZD3
- Frizzled3 (FZD3) is implicated in aggressive phenotypes of small cell lung cancer (SCLC).
- The study combines bioinformatics and experimental validation to explore FZD3's role in SCLC progression.
- Analysis of transcriptomic data from 102 SCLC and 55 normal lung tissues identified 1,192 differentially expressed genes.
- FZD3 was selected as a key hub gene and found to be upregulated in SCLC tissues and cell lines.
- High FZD3 expression correlates with advanced clinical stage and poor prognosis in SCLC patients.
- Functional assays showed that FZD3 knockdown reduces SCLC cell proliferation, migration, and invasion while increasing apoptosis.
- FZD3 is proposed as a potential therapeutic target and prognostic biomarker in SCLC.