Kynurenic Acid/GPR35 Signaling Protects the Infarcted Heart by Suppressing Macrophage mtDNA-Triggered cGAS-STING Activation - PubMed
8 hours ago
- #Kynurenic Acid
- #Macrophages
- #Myocardial Infarction
- Kynurenic acid (KynA) improves cardiac function and reduces scarring and fibrosis in a mouse model of myocardial infarction (MI).
- The cardioprotective effects of KynA are mediated through its receptor GPR35 and require macrophages, as depletion of macrophages abolishes these benefits.
- KynA suppresses pro-inflammatory responses in macrophages by inhibiting mitochondrial DNA leakage and downregulating the cGAS-STING signaling pathway.