NOX1/4 drives hepatic iron and lipid dysregulation, redox imbalance, and inflammation in ethanol-fed mice - PubMed
5 days ago
- #NOX1/4
- #Alcoholic liver disease
- #Setanaxib
- NOX1/4 plays a central role in ethanol-induced liver injury, contributing to iron overload, oxidative stress, and inflammation.
- Setanaxib, a NOX1/4 inhibitor, shows therapeutic potential by attenuating liver injury, iron overload, hepatic steatosis, and oxidative stress.
- Mechanistically, Setanaxib restores iron homeostasis, activates antioxidant defenses, and reduces inflammation in ethanol-fed mice.
- The study highlights NOX1/4 as a key regulator in alcoholic liver disease (ALD) pathogenesis and Setanaxib as a promising multi-target therapy.