Angiotensin-(1-7) Alleviates Isoproterenol-Induced Cardiac Hypertrophy by Suppressing Autophagy and Apoptosis Through the Synergistic Action of Mas Receptor and Angiotensin II Type 2 Receptor - PubMed
3 hours ago
- #Receptor Signaling
- #Angiotensin-(1-7)
- #Cardiac Hypertrophy
- Ang-(1-7) alleviates ISO-induced cardiac hypertrophy by suppressing excessive autophagy and apoptosis.
- The protective effects involve synergistic signaling through both MasR and AT2R.
- Anti-apoptotic effects require both receptors, while anti-autophagic effects are mainly MasR-mediated.
- Pharmacological blockade and co-immunoprecipitation confirmed receptor interaction and coordinated action.
- Receptor crosstalk represents a potential therapeutic target for pathological cardiac hypertrophy.