Celosiae Semen and Celosin I alleviate postmenopausal osteoporosis by inhibiting ferroptosis through the Nrf2/GPX4 pathway - PubMed
4 days ago
- #osteoporosis
- #Nrf2/GPX4 pathway
- #ferroptosis
- Celosiae Semen (CS) and Celosin I (CI) alleviate postmenopausal osteoporosis (PMOP) by inhibiting ferroptosis through the Nrf2/GPX4 pathway.
- Network pharmacology and HPLC analysis identified CS-related targets and components.
- In vivo studies showed TSCS and CI improved bone mineral density and trabecular structure in ovariectomized mice.
- In vitro, TSCS and CI reduced lipid peroxidation, restored glutathione levels, and upregulated Nrf2 and GPX4 in BMSCs.
- Molecular docking confirmed strong binding affinity of CI for Nrf2 and GPX4.
- Nrf2 knockout models demonstrated the dependence of TSCS and CI effects on the Nrf2/GPX4 pathway.
- TSCS and CI are promising candidates for targeting ferroptosis in osteoporosis treatment.