Genomic landscape, immune microenvironment and survival in male versus female breast cancer - PubMed

3 days ago

Male breast cancer (MaBC) represents ~1% of breast malignancies and shows significant differences compared to female breast cancer (FeBC).
The study analyzed whole-transcriptome and whole exome sequencing from 19,697 tumor samples to characterize molecular and immune differences.
Key findings include differences in mutation frequencies (e.g., TP53, ESR1, BRCA2, CDH1) between MaBC and FeBC across molecular subtypes.
Immunologically, MaBC exhibited increased M2 macrophages, decreased dendritic cell infiltration, and reduced immune checkpoint gene expression (PDCD1, LAG3).
The study suggests a unique genomic and immunologic landscape in MaBC, requiring a sex-informed approach for treatment and resistance mechanisms.

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