Cilia-independent gas-liquid transport, a third mechanism mediating airway mucus clearance - PubMed
3 hours ago
- #cilial dysfunction
- #mucus clearance
- #respiratory physiology
- Airway mucus clearance occurs via three mechanisms: cilia-mediated, cough-mediated, and cilia-independent gas-liquid transport (GLT).
- GLT is a newly recognized mechanism that operates during normal tidal breathing and is independent of cilia function.
- In vitro and in vivo studies confirm that GLT is airflow-dependent and influenced by mucus concentration.
- GLT clearance rates are affected by breathing frequency and body orientation.
- GLT may be particularly beneficial for individuals with cilial dysfunction.
- Potential therapies to enhance GLT include exercise, mucus rehydrating agents, and mucolytics.