Vitamin D receptor drives macrophage M2 polarization and exacerbates airway inflammation in asthma - PubMed
3 hours ago
- #Asthma
- #Vitamin D Receptor
- #Macrophage Polarization
- Vitamin D receptor (VDR) expression increases in macrophages upon house dust mite exposure, both in vivo and in vitro.
- Myeloid-specific deletion of Vdr in mice reduces airway inflammation, inflammatory cell recruitment, and epithelial damage in a chronic asthma model.
- VDR promotes M2-like polarization of macrophages, contributing to worsened allergic airway inflammation.
- A newly identified C-terminal nuclear localization sequence (NLS) in VDR (amino acids 387-412) is crucial for its nuclear translocation and macrophage polarization.
- Phosphorylation within this NLS enhances VDR's interaction with the nuclear import adaptor KPNA1, facilitating nuclear import.