Cardiovascular health factors and altered proteomic landscapes in the progression of cardiovascular-kidney-metabolic syndrome: Evidence from multi-cohorts in China, the UK, and the US - PubMed
3 hours ago
- #Cardiovascular Health
- #Proteomics
- #CKM Syndrome
- Study examines cardiovascular health (CVH) factors and proteomic profiles in cardiovascular-kidney-metabolic (CKM) syndrome progression.
- Data analyzed from cohorts in China (CHARLS), the UK (UK Biobank), and the US (NHANES), totaling over 255,000 participants.
- Optimal CVH linked to reduced risks of CVD and all-cause mortality across all cohorts.
- A panel of 722 proteins identified, associated with lower CVD risk (41%) and all-cause mortality (54%).
- Proteins, particularly ALPP, mediate CVH's protective effects on CKM syndrome progression and prognosis.
- Findings suggest CVH behaviors and proteomic biomarkers could improve CKM syndrome outcomes.