HAND1 controls the lineage bifurcation of trophoblast and amnion from human pluripotent stem cells - PubMed
a day ago
- #stem cells
- #HAND1
- #lineage specification
- HAND1 is identified as a critical transcription factor controlling the bifurcation of trophoblast and amniotic lineages from human pluripotent stem cells (hPSCs).
- Genetic ablation of HAND1 enhances trophoblast differentiation while impairing amniotic differentiation.
- Ectopic HAND1 overexpression inhibits trophoblast differentiation and promotes amniotic lineage specification.
- HAND1 interacts with TCFs and β-catenin to form a transcriptional complex that modulates trophoblast- and amnion-associated gene regulatory networks.
- The study provides insights into the regulatory mechanisms of extra-embryonic lineage specification during hPSC differentiation.