Amelioration of colorectal cancer-associated fibroblasts in immunosuppressive microenvironment by ferroptosis-based nanotherapy - PubMed
6 days ago
- #immunotherapy
- #colorectal cancer
- #ferroptosis
- Colorectal cancers (CRCs) are often resistant to immunotherapy due to cancer-associated fibroblasts (CAFs) promoting tumor growth and immunosuppression.
- A new treatment strategy uses magnetic nanoparticles to target CAFs, inducing ferroptosis (a form of cell death) through iron and copper ions.
- These nanoparticles also remodel the tumor microenvironment by breaking down physical barriers and activating the immune system, particularly dendritic cells and CD8+ T cells.
- The effectiveness of this approach is validated in patient-derived xenograft and organoid models, showing potential for clinical translation.
- The strategy offers a promising avenue for CRC treatment by addressing both structural and immunosuppressive challenges in the tumor microenvironment.