Efficacy and Safety of Pharmacologic Therapies in Acromegaly: A Systematic Literature Review and Network Meta-Analysis - PubMed
4 hours ago
- #Pharmacological Treatments
- #Acromegaly
- #Network Meta-Analysis
- Limited head-to-head trials comparing pharmacological treatments for acromegaly.
- Systematic review and network meta-analysis (NMA) conducted to evaluate efficacy and safety.
- 22 records covering 18 RCTs included in the analysis.
- Biochemical control rates comparable among long-acting injectable somatostatin receptor ligands (SRLs).
- Paltusotine showed significantly higher biochemical control versus O-OCT and SC-OCT-D.
- Pasireotide demonstrated higher biochemical control versus OCT-LAR.
- Paltusotine had lower discontinuations due to adverse events (AEs) compared to O-OCT and SC-OCT-D.
- Treatment-emergent AEs (TEAEs) and serious TEAEs were comparable across treatments.
- Paltusotine ranked highest in probability for effectiveness and tolerability.
- Paltusotine emerges as a promising alternative to injectable SRLs with favorable efficacy and safety.