Integrative Single-Cell and Spatial Transcriptomic Analysis Reveals MAIT Cell Dysfunction in Relapsed HCC - PubMed
6 hours ago
- #HCC relapse
- #spatial transcriptomics
- #MAIT cells
- The study used integrative single-cell and spatial transcriptomics to analyze tumor samples from primary and relapsed HCC patients.
- Relapsed HCC showed increased malignant hepatocytes with elevated cancer stemness signatures compared to primary tumors.
- MAIT cells were significantly enriched in relapsed tumor regions and displayed a dysfunctional phenotype.
- Enhanced interactions were found between MAIT cells and malignant hepatocytes in relapsed tumors.
- High relapsed MAIT cell signature scores correlated with poorer overall survival in the TCGA LIHC cohort.
- The findings suggest MAIT cell dysregulation is associated with relapse-specific tumor biology in HCC.