Antigen in bird flu A(H5) virus confers subtype-wide immunity
a day ago
- #pandemic preparedness
- #vaccine
- #influenza
- A vaccine antigen central in influenza A(H5) virus antigenic space provides broad immunity across the subtype.
- Highly pathogenic avian influenza A(H5) viruses pose a global threat to birds, mammals, and humans, highlighting pandemic potential.
- The study created a high-resolution antigenic map to track the global evolution of A(H5) hemagglutinin (HA).
- Engineered vaccine HA antigens elicited broad antibody responses covering the A(H5) antigenic space.
- In ferrets, the central antigen offered protection comparable to homologous vaccines against heterologous infections.
- The research demonstrates rational design for subtype-wide influenza A(H5) pre-pandemic vaccines.
- Antigenic maps are valuable for evaluating vaccine-induced immune responses through antibody profiles.