Liver-pancreas communication in disease and drug development - PubMed
4 hours ago
- #Metabolic Diseases
- #Liver-Pancreas Crosstalk
- #Drug Development
- The liver and pancreas engage in critical bidirectional communication essential for systemic homeostasis.
- Dysregulated liver-pancreas crosstalk contributes to diseases like MASLD, liver cancer, pancreatitis, and diabetes.
- There are currently no FDA-approved drugs for alcohol-associated liver disease or acute/chronic pancreatitis.
- Communication involves hepatokines, hormones, extracellular vesicles, and metabolic exchanges, integrated with gut, neuronal, and other tissue networks.
- Potential therapies like FGF21- and bile acid-related drugs are under research, with future efforts focusing on small molecular drug discovery for metabolic diseases.