Cerebrospinal fluid NPTX1 and NPTXR predict neurodegeneration and clinical progression in Alzheimer's disease - PubMed
3 days ago
- #Alzheimer's disease
- #biomarkers
- #neurodegeneration
- CSF levels of NPTX1 and NPTXR are strong indicators of Alzheimer's disease severity and progression.
- Lower CSF NPTX levels correlate with cognitive impairment and cortical thinning in AD-vulnerable brain regions.
- Baseline NPTX levels predict faster brain atrophy and transition from mild cognitive impairment to dementia.
- NPTX biomarkers often outperform or complement established markers like pTau181 and neurofilament light chain.
- These biomarkers enhance patient stratification and monitoring of disease-modifying therapies in clinical trials.