LAMC3 promotes the development of prostate cancer via modulating the cell cycle progression - PubMed
4 hours ago
- #Cell Cycle
- #Prostate Cancer
- #LAMC3
- LAMC3 is significantly upregulated in prostate cancer (PCa) compared to benign prostatic hyperplasia (BPH).
- Knockdown of LAMC3 inhibits cellular proliferation, clonogenic potential, and induces G1/S phase cell cycle arrest in PCa.
- LAMC3 suppression leads to inhibition of the PI3K/Akt pathway, downregulating CDKN1A (p21) and CDKN1B (p27).
- In vivo experiments show that LAMC3 silencing suppresses tumor growth and synergizes with PI3K inhibitors for antitumor effects.
- LAMC3 is identified as a key regulator of cell cycle progression in PCa and a potential therapeutic target.