Evolution and Transformation of Hypertrophic Cardiomyopathy From a High Risk to a Treatable Low Mortality Disease With Contemporary Clinical Research Strategies - PubMed
4 hours ago
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- Hypertrophic cardiomyopathy (HCM) has evolved from a rare, untreatable disease with high mortality to a manageable condition with low mortality (≤0.5%/year).
- Key advancements include implantable defibrillators (95% effective in preventing sudden death), surgical myectomy (successful in >90% of cases), and aggressive anticoagulation (reducing stroke risk).
- Contemporary treatment strategies, including novel cardiac myosin inhibitors, have improved symptom relief and disease management.
- Dedicated HCM programs and observational studies have driven evidence-based treatment approaches.
- Modern HCM patients can achieve normal longevity, a significant improvement over past generations.