Phospholipid-driven conformational switching of HCV NS5A links protein folding to replication membrane remodeling - PubMed
3 hours ago
- #conformational switch
- #HCV replication
- #lipid-protein interaction
- Phospholipids, especially phosphatidylinositol-4-phosphate (PIP), drive conformational switching in HCV NS5A protein.
- This lipid-driven switch promotes NS5A dimerization, linking lipid sensing to membrane remodeling and host factor recruitment.
- The mechanism involves an alternative membrane-specific fold stabilized by polyproline hinges and PIP binding.
- The antiviral drug pibrentasvir blocks this reciprocal lipid-protein interaction.
- Dynamic lipid-protein interfaces are highlighted as targets for antiviral intervention.