Intestinal Stem Cells from Patients with Inflammatory Bowel Disease Retain an Epigenetic Memory of Inflammation - PubMed
7 hours ago
- #Intestinal Stem Cells
- #Epigenetic Memory
- #Inflammatory Bowel Disease
- Intestinal stem cells from IBD patients maintain epigenetic memory of inflammation even after healing.
- Chromatin accessibility studies reveal 2,250 unique regions in inflamed organoids linked to stress response.
- These primed cells show heightened wound closure and gene expression upon re-challenge.
- The memory persists without immune cues, possibly aiding adaptation but increasing relapse risk.