Ginsenoside Rg1 mitigates sepsis-associated acute respiratory distress syndrome by promoting autophagy through the Prdx1-PTEN/PI3K/AKT pathway - PubMed
4 days ago
- #Sepsis
- #Autophagy
- #Ginsenoside Rg1
- Ginsenoside Rg1 mitigates sepsis-associated acute respiratory distress syndrome (ARDS) by promoting autophagy.
- The study explores the Prdx1-PTEN/PI3K/AKT pathway as the mechanism behind Rg1's therapeutic effects.
- Both in vivo (mouse models) and in vitro (alveolar epithelial cells) experiments were conducted.
- Rg1 enhances the Prdx1-PTEN interaction, inhibiting the PI3K/AKT pathway, leading to increased autophagy and reduced apoptosis, inflammation, and oxidative stress.
- The findings suggest Rg1 as a potential therapeutic for sepsis-induced ARDS, pending further clinical research.